One more discussion starter... 
"Brain in a vat" is the name for an idea: that a person's brain may be removed and put in a tank filled with fluid to keep it alive, then connected to a computer which would feed it electrical impulses which, to the brain, would be indistinguishable from those a brain in a real body, in the real world, receives.
If it was done "perfectly" (which, of course, isn't even close to being possible with current technology), a person might live an entire "life" in a simulated reality, thinking he or she had a growing body, friends, and so on. They could be "born", live and die, while being nothing more than a disembodied brain in the vat.
While this happens commonly in science fiction, philosophers have also discussed this in the past. Indeed, the idea is that we might be a brain in a vat now, and never know it. (No, I'm not that paranoid!
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As for fictional examples, probably the best known is The Matrix, though that one was a shared virtual reality (in a way, much like an incredibly more advanced massively multiplayer online game); in other words, everyone in the "vats" was a "character" in the same virtual reality. (Also, the entire bodies were kept, not just the brains.)
Typically, however, in the "brain in a vat" thought experiment, you might be the only brain in the tank; everyone else you meet would be part of the same simulation.
Again, I don't believe such a thing is the case, in real life (though, if it was, "real life" wouldn't be what I think it is...). But, if it was, what would be different?
Quoting from Sid Meier's Alpha Centauri:
"[...] does my life gain or lose meaning based on my reaction to such solipsism?"
In other words, if it was true... what would change? Would our lives lose "meaning"?
Well, if it was true, we could never know, we could never find out (unless the simulation was imperfect in some way, like in The Matrix). So, the best thing would be... to ignore it. To live your live under the assumption that that life is real, and do the best thing you can with it.
"The real thing" and a 100% perfect simulation are, by definition, indistinguishable...
Any thoughts?